Nucleus pulposus cells as competent phagocytes to clear apoptotic cells: mission applicable or impossible?

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Nucleus pulposus cells as competent phagocytes to clear apoptotic cells: mission applicable or impossible? Authors' response

Page 1 of 1 (page number not for citation purposes) We thank Dr Wang and Dr Luo for their interest in our paper demonstrating the ability of intervertebral disc cells to undergo phagocytosis [1], and we can certainly concur with some of the points they raise [2]. In fact, we addressed the first point in the last paragraph of the Discussion, stating that ‘Although disc cells usually occur in iso...

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Nucleus pulposus cells as competent phagocytes to clear apoptotic cells: mission applicable or impossible?

We have read with interest the research article by Philip Jones and colleagues, in which they studied whether bovine nucleus pulposus (NP) cells were capable of behaving as phagocytes [1]. Collectively, they drew the conclusion that disc cells clearly can undergo phagocytosis, which has implications for the intervertebral disc in vivo. We would like to differ from the authors, however, regardin...

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INTRODUCTION The cells of the embryonic notochord play an important role in formation of the spinal column, including the intervertebral discs (IVDs) (1). These cells become trapped inside the annulus fibrosus and reside within the nucleus pulposus at birth, but are generally lost during aging and replaced by small chondrocyte-like cells. The age at which the notochordal cells are lost varies s...

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ژورنال

عنوان ژورنال: Arthritis Research & Therapy

سال: 2009

ISSN: 1478-6354

DOI: 10.1186/ar2647